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Short-Term Supplement Model for Human Subjects Research Supported by Foreign Subawards
To address concerns for participant safety risks for ongoing projects, NIH has established a short-term supplement model to support clinical research and clinical trials conducted under an active foreign subaward.
How Does the NIH Initiative to Prioritize Human-Based Research Affect Research Proposing the Use of Laboratory Animals?
In July 2025, NIH announced it will no longer develop new funding opportunities focused exclusively on animal models of human disease. Rather, going forward, new funding opportunities will be designed more broadly with language that also encourages various approaches be considered.
NIH Fellowship Funding Opportunities Are Here
Updated funding opportunities for NIH fellowships are below and also available on the NIH Guide for Grants and Contracts and Grants.gov. NIH fellowships are open to early career scientists, including at the predoctoral and postdoctoral level, and are designed to provide mentored research training to enable skills’ development and experiences needed to transition into careers in the biomedical research workforce.Â
NIH Funding Announcements to Align with NIH Initiative to Prioritize Human-based Research
On April 29, NIH announced it is prioritizing human-focused research and reducing animal use in research. To further this initiative, all new Notices of Funding Opportunity that relate to animal model systems (NOFOs) must now also support human-focused approaches such as clinical trials, real world data, or new approach methods (NAMs).